All about Haploid Bone Marrow Transplant

Bone marrow transplant in India is performed on people whose bone marrow is not healthy enough to process out some specific parts of the blood which comprises of red blood cells, white blood cells, and platelets, all of these have significant functions for proper working of the body. If the bone marrow is not healthy, hematopoietic stem cells (bone marrow is also composed of these) can fail to make new cells. Bone marrow transplant specialist states the possible reasons and risk factors which lead to an inapt working of bone marrow, they usually include chronic infections, disease, cancer such as leukaemia and lymphoma and its treatment as well. Aplastic anemia affects the new blood cell forming capability of bone marrow. Genetics can also cause disease which can affect proper functioning of bone marrow, common examples are sickle cell anemia and thalassemia.

To cure these cases, bone marrow transplant has developed as a medical procedure to transplant healthy stem cells into patient’s body. Bone marrow transplant specialist recommend only the best services because the procedure needs on-hands successful experience and world class technological support. The process of bone marrow transplant has been  developed and many varieties are in reach now which include autologous transplants, allogeneic transplants, haploidentical bone marrow transplants, syngeneic, and matched and unrelated Donor (MUD). Out of these, haploidentical bone marrow transplant works on the principle of inheritance and it has showcased successful numbers of  cases  on the  similar lines  of traditional transplant procedures. During development of embryo in the mother's womb, both parents transfer HLA antigens to the embryo. As per the laws of nature, set of HLA antigens are inherited by the baby. This makes mother and child as natural donors for each other. The combination is half matched in their HLA (human leukocyte antigens) but it proves successful for a healthy bone marrow transplant. Haploid bone marrow transplant in Delhi specifies that a half HLA matched sibling, parent, and children can be a successful donor for healthy bone marrow transplant. Haploidentical bone marrow transplant is a proven alternative BMT for patients who don't have a fully HLA matched family donor or a matched unrelated donor.

The donor selection for haploidentical bone marrow transplant is not solely based on first blood relations of the patients. Instead, it is of primary concern to evaluate all the medical aspects of both patient and donor for satisfactory results of bone marrow transplantation. There are some basic guidelines which are followed up by well-known institutions of bone marrow transplant in India for proper assessment of the donor and patience. The success of haploidentical bone marrow transplant depends upon the close match between the markers of recipient's HLA and those of the donor. Physical examination of the patient is carried out to determine his/her health and the severity of the medical condition. Further, laboratory tests are performed to assess the levels of specific cell types and receptors in blood in both patient and donor. Donor also undergo certain tests which confirm the levels (if present) of anti-cancer cells.

Haploid bone marrow transplant in Delhi is performed on the terms of medically approved  procedure. Firstly, a right donor is selected which is first family member in the case of haploidentical BMT. To clean the presence of malignant  areas, chemotherapy or  radiation therapy (or a combination of  both) is performed on the patient. This ia followed up by transfer of healthy bone marrow from the chosen donor. Post-transplantation, usually after three days, a high dose of cyclophosphamide is injected into the patient's body to clean the immune system and it accords the donor's stem cells to create a new immune system.